The scientists have identified a MHC Class ll haplotype associated with an increased risk of Vizsla Inflammatory Polymyopathy. We are still a considerable way from our goal of being able to determine which vizslas have the potential to carry forward an expression of the disease – but the published research findings are a very exciting step in the right direction.
Please do take time to read the abstract It explains that the current research into VIP has the potential to help human sufferers of myositis – and indeed other inheritable inflammatory disorders. Pedigree dog breeds that display high predisposition for certain spontaneously occurring diseases have already proved to represent a powerful comparative genetic model for aiding in the discovery of novel genetic loci underlying analogous human conditions.
The purpose of the research is to develop a screening test.
Since publication we have continued to submit saliva samples from affected dogs and graded controls. The dataset now comprises c 530 dogs. Lorna Kennedy and her team at CIGMR have now extracted DNA and DLA typed most of these samples. Further analysis of the data has confirmed an increased significance for all the associations. This is an exciting finding and we are hoping that Lorna’s studies can now proceed to further interrogation of the information provided on the SNP arrays. This work is very labour intensive and so continuing funding is crucial.
The researchers have specifically thanked the owners that have provided their vizslas’ samples. They have also placed on record their appreciation of the generous financial donations provided by the Hungarian Vizsla Club and now the Hungarian Vizsla Welfare Charity.