Immune Mediated  Illness in the Hungarian Vizsla                
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POLYMYOSITIS IN THE HUNGARIAN VIZSLA

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Please click on the tabs above for all the latest information. There have been recent veterinary developments and there is now a DNA collection scheme.

see also        http://vizslamyositis.blogspot.com/

2012 - January - ( site under construction)

There is a newly recognised disease in the Hungarian Vizsla. It is a breed associated presentation of Polymyositis. The principal clinical signs are swallowing problems, excessive foamy drooling and muscle wasting (especially around the head) See Vet Info tab above. We need to hear from any vizsla owner that has had experience of this disease.

     

Radio before Polymyositis                                     Radio after Polymyositis ^

Please look at the video clips in the sidebar to see typical swallowing problems - these are usually at the level of the pharynx. The tongue muscles too are often involved. Picking up food can be difficult and normal lapping and licking can be compromised.

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Jasper before Polymyositis                                                 Jasper after Polymyositis                   

Polymyositis in the young vizsla often presents with an acute episode of retching, gagging, choking, dysphagia and hypersalivation. Sometimes in the case of older individuals the onset is more insidious with just inefficient and messy eating and drinking being previously noted. Frequently there is an initial diagnosis of megaoesophagus. Fatigue, significantly elevated CK levels, an absence of a gag reflex, voice change, aspiration pneumonia, lameness/stiffness/peculiarity of gait are other common findings. Muscle wasting in the temporal and masseter areas usually follows. Where cases have been fully investigated, infectious causes of muscle inflammation (such as neosporosis or toxoplasmosis) are invariably ruled out. So too are two similar diseases - Myasthenia Gravis and Masticatory Muscle Myositis. Here is an important document prepared by G. Diane Shelton DVM, PhD, DACVIM to help veterinarians correctly distinguish and diagnose muscle disease in the vizsla. Here is a presentation on her website

                

Mika drool                                                                                       Spice drool

Polymyositis in the vizsla has been especially noted in the UK but has now been reported in other parts of Europe and also US, Canada, Australia and New Zealand.

This is Hunter - from Canada - he was a case study submitted by Susan Cochrane to ACVIM. Two years after diagnosis and treatment he is doing very well.

          

Hunter                                                                                    Hunter

PM in the Vizsla is believed to be immune mediated and on the basis of several very close family relationships (siblings for example) considered to be genetic ie inheritable. Please visit the pedigrees tab above to see an open registry of affected UK individuals

With prompt diagnosis and treatment polymyositis can usually be well controlled with combined immune suppressive protocols - typically Prednisone + Imuran (azathioprine) + gastroprotectants - these medications to be only very gradually tapered. Recently some specialists have also introduced Cyclosporine/Atopica (another immune suppressant) Careful monitoring of these regimes is vital. Here is a well referenced protocol that gives excellent advice on the benefits of taking things slowly and staying receptive to a need to respond to any resurgence of clinical signs. Once remission has been achieved many UK PM vizslas have benefitted from long term "maintenance" doses of steroids - at just anti inflammatory levels. There are lots of happy success stories - and this website will be updated shortly to describe them.

 

 

Research

CLARE RUSBRIDGE

(BVMS, PhD, DipECVN, MRCVS) RCVS and European Specialist in Veterinary Neurology

Visit Clare's website

Exciting news about a scheme to collect DNA from PM affected vizslas and their relatives. Click here for information and instructions. The hope is to develop a DNA "test" for polymyositis.

We are hugely indebted to Clare for her help.

See also DNA collection tab above


DYSPHAGIA-

video clips of swallowing difficulties

Spice eating

Spice drinking

Amber eating

Harvey drinking
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  *CONTACT*

  Di Addicott - Murrayfield, Lockerbie, Dumfriesshire, DG11 2PJ  (UK)

   di.addicott@gmail.com Tel 01576 202258

 

*VIZSLA OWNERS*

*you* hold the key to the success of the DNA collection project and your help is desperately needed. The project needs saliva samples from the relatives of affected vizslas. Please email Di Addicott (project coordinator) or pick up the phone (01576 202258) to say "my vizsla's pedigree name is XXX - would his saliva sample be useful"

It does NOT mean that your vizsla is likely to develop PM - not at all. All communications are dealt with speedily and in strict confidence.

Every single relevant sample contributes hugely to the research and brings us a step closer to developing that vital DNA test. One day PM in the vizsla will be history but we need vizsla lovers to come forward with a readiness to help. Please make contact. All participants are provided with everything that is required - the sample is quick and easy to take - and there are absolutely no costs to the owner. Even the postage is prepaid. Confidentiality is assured. Please help

      *BREEDERS*

please include this information leaflet in your Puppy Packs

     POLYMYOSITIS IN OTHER BREEDS?

VET PAPERS

GWPs ( affected littermates)

Newfoundlands (affected dam and 2 other littermates)

 

 
*Where it all started* - a Hungarian Vizsla Club Newsletter in 2006

Description of the Illness here
Radio's Story here
Jasper's Story here
Sad Story here
 

to follow shortly

CIMDA
other breeds
breed resources
happy stories